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To provide additional ?ow to washout the instrumental dead space, the insertion inthe lumen of the ETT of a catheter large enoughto avoid high-pressure and high-velocity ?owwould increase the inspiratory and expiratoryresistance by signi?cantly reducing the lumen’sdiameter. This may occur, to a small extent, in cross-sectional studies, such as in theexample in Box 5.5 in which study participants recorded dietary data over aweek, but for a cohort study, data need to be collected over a much longer timeperiod (usually months, sometimes years)

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Padilla GV, Grant MM, Lipsett J, Anderson PR, Rhiner M, Bogen C. These patients are commonly hypotensive whenmaintained under general anesthesia

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